Assay Detail
Functional
CHEMBL830001
Review assay metadata, readout intent, target linkage, and publication context from the same page.
GR-mediated transrepression of IL-6 in human A549 lung carcinoma cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 7.99 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310570 | — | — | 1 | 9.02 |
| CHEMBL371376 | — | — | 1 | 8.57 |
| CHEMBL82546 | — | — | 1 | 8.49 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.35 |
| CHEMBL372684 | — | — | 1 | 8.22 |
| CHEMBL79807 | — | — | 1 | 8.01 |
| CHEMBL193404 | — | — | 1 | 7.89 |
| CHEMBL362914 | — | — | 1 | 7.89 |
| CHEMBL313062 | — | — | 1 | 7.84 |
| CHEMBL363179 | — | — | 1 | 7.75 |
| CHEMBL195972 | — | — | 1 | 7.72 |
| CHEMBL364015 | — | — | 1 | 7.68 |
| CHEMBL194077 | — | — | 1 | 7.51 |
| CHEMBL196347 | — | — | 1 | 7.43 |
| CHEMBL365818 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310570 | — | EC50 | = | 0.96 | nM | 9.02 |
| CHEMBL371376 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL82546 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL131 | PREDNISOLONE | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL372684 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL79807 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL193404 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL362914 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL313062 | — | EC50 | = | 14.4 | nM | 7.84 |
| CHEMBL363179 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL195972 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL364015 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL194077 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL196347 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL365818 | — | EC50 | = | 38.0 | nM | 7.42 |