Assay Detail
Binding
CHEMBL830008
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Effective concentration against telomerase by TRAP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.82 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182871 | — | — | 1 | 7.10 |
| CHEMBL184587 | — | — | 1 | 7.01 |
| CHEMBL336434 | — | — | 1 | 6.95 |
| CHEMBL184481 | — | — | 1 | 6.78 |
| CHEMBL182411 | — | — | 1 | 6.57 |
| CHEMBL181970 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182871 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL184587 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL336434 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL184481 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL182411 | — | EC50 | = | 267.0 | nM | 6.57 |
| CHEMBL181970 | — | EC50 | = | 318.0 | nM | 6.50 |