Compound Detail
CHEMBL184481
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CN1CCN(C(=O)CCCCC(=O)Nc2ccc(Nc3c4ccc(NC(=O)CCN5CCCC5)cc4nc4cc(NC(=O)CCN5CCCC5)ccc34)cc2)CC1
Basic Information
| ChEMBL ID | CHEMBL184481 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KMACCIHWEXFGFT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
776.0
MW (Da)
6.25
ALogP
9
HBA
4
HBD
142.2
PSA (Ų)
0.08
QED
2
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.78
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | EC50 | 6.78 | 6.78 | 165.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | EC50 | = | 165.0 | nM | 6.78 | Effective concentration against telomerase by TRAP | 15261300 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15261300 | 10.1016/j.bmcl.2004.05.090 | Telomerase reverse transcriptase | 1 |
| 15261300 | 10.1016/j.bmcl.2004.05.090 | Nucleic Acid | 1 |
Data from ChEMBL 36 via Core Engine