Assay Detail
Binding
CHEMBL830050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant against Adenosine A1 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Binding thermodynamics as a tool to investigate the mechanisms of drug-receptor interactions: thermodynamics of cytoplasmic steroid/nuclear receptors in comparison with membrane receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.64 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 8.07 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 5.23 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.92 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Kd | = | 8.6 | nM | 8.07 |
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | Kd | = | 5900.0 | nM | 5.23 |
| CHEMBL1355736 | THEOPHYLLINE | Kd | = | 12000.0 | nM | 4.92 |
| CHEMBL113 | CAFFEINE | Kd | = | 45000.0 | nM | 4.35 |