Assay Detail
Binding
CHEMBL830078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
ATP-binding cassette sub-family C member 8 (CHEMBL2071) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro evaluation of (S)-2-([11C]methoxy)-4-[3-methyl-1-(2-piperidine-1-yl-phenyl)-butyl-carbamoyl]-benzoic acid ([11C]methoxy-repaglinide): a potential beta-cell imaging agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.08 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1272 | REPAGLINIDE | 4.0 | 1 | 7.30 |
| CHEMBL360610 | — | — | 1 | 7.08 |
| CHEMBL186684 | — | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1272 | REPAGLINIDE | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL360610 | — | Kd | = | 83.0 | nM | 7.08 |
| CHEMBL186684 | — | Kd | = | 134.0 | nM | 6.87 |