Compound Detail
CHEMBL186684
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Basic Information
| ChEMBL ID | CHEMBL186684 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SOUVIYRQMIWZAJ-QHCPKHFHSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
470.6
MW (Da)
5.17
ALogP
4
HBA
2
HBD
78.9
PSA (Ų)
0.47
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.55
Kd 1 meas. best 6.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ATP-binding cassette sub-family C member 8 CHEMBL2071 | Kd | 6.87 | 6.87 | 134.0 | 1 |
| ATP-binding cassette sub-family C member 8 CHEMBL2071 | IC50 | 6.55 | 6.55 | 281.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ATP-binding cassette sub-family C member 8 | Kd | = | 134.0 | nM | 6.87 | Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea recep... | 15380228 |
| ATP-binding cassette sub-family C member 8 | IC50 | = | 281.0 | nM | 6.55 | In vitro displacement of [3H]glibenclamide (IC50=0.61) from COS-1 cells expressi... | 15380228 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15380228 | 10.1016/j.bmcl.2004.07.059 | ATP-binding cassette sub-family C member 8 | 2 |
Data from ChEMBL 36 via Core Engine