Assay Detail
Binding
CHEMBL830097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration to enhance [3H]-GABA binding to Gamma-aminobutyric acid A receptor in rat cerebrocortical membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis, structure-activity relationships at the GABA(A) receptor in rat brain, and differential electrophysiological profile at the recombinant human GABA(A) receptor of a series of substituted 1,2-diphenylimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 4.06 | 4.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193243 | — | — | 1 | 4.06 |
| CHEMBL190737 | — | — | 1 | - |
| CHEMBL193201 | — | — | 1 | - |
| CHEMBL192900 | — | — | 1 | - |
| CHEMBL426986 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193243 | — | EC50 | = | 87790.0 | nM | 4.06 |
| CHEMBL190737 | — | EC50 | = | 12390000.0 | nM | - |
| CHEMBL193201 | — | EC50 | = | 1591000.0 | nM | - |
| CHEMBL192900 | — | EC50 | = | 684000.0 | nM | - |
| CHEMBL426986 | — | EC50 | = | 2087000.0 | nM | - |