Assay Detail
Binding
CHEMBL830124
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against sarco- endoplasmic reticulum calcium-ATPase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (CHEMBL3136) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Applying linear interaction energy method for rational design of noncompetitive allosteric inhibitors of the sarco- and endoplasmic reticulum calcium-ATPase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.59 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365703 | — | — | 1 | 8.92 |
| CHEMBL191633 | — | — | 1 | 8.68 |
| CHEMBL191927 | — | — | 1 | 7.70 |
| CHEMBL362947 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365703 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL191633 | — | IC50 | = | 2.08 | nM | 8.68 |
| CHEMBL191927 | — | IC50 | = | 19.83 | nM | 7.70 |
| CHEMBL362947 | — | IC50 | = | 9038.0 | nM | 5.04 |