Assay Detail
Binding
CHEMBL830207
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Competitive inhibition constant for Acetylcholinesterase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.71 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL179455 | — | — | 1 | 8.83 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.82 |
| CHEMBL361165 | — | — | 1 | 6.05 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 5.15 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL179455 | — | Ki | = | 1.49 | nM | 8.83 |
| CHEMBL95 | TACRINE | Ki | = | 151.0 | nM | 6.82 |
| CHEMBL361165 | — | Ki | = | 894.0 | nM | 6.05 |
| CHEMBL345124 | PROPIDIUM | Ki | = | 7140.0 | nM | 5.15 |
| CHEMBL11805 | CAPROCTAMINE | Ki | = | 104.0 | nM | - |