Assay Detail
Binding
CHEMBL830210
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Inhibitory concentration against the plasmepsin-2 of Plasmodium falciparum
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.74 | 9.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113208 | — | — | 1 | 9.25 |
| CHEMBL264770 | — | — | 1 | 9.05 |
| CHEMBL191260 | — | — | 1 | 8.96 |
| CHEMBL191130 | — | — | 1 | 8.96 |
| CHEMBL371417 | — | — | 1 | 8.72 |
| CHEMBL112598 | — | — | 1 | 8.66 |
| CHEMBL33989 | — | — | 1 | 8.37 |
| CHEMBL363286 | — | — | 1 | 8.36 |
| CHEMBL190290 | — | — | 1 | 8.24 |
| CHEMBL113331 | — | — | 1 | 8.00 |
| CHEMBL370086 | — | — | 1 | 7.89 |
| CHEMBL364630 | — | — | 1 | 7.80 |
| CHEMBL189976 | — | — | 1 | 7.72 |
| CHEMBL371182 | — | — | 1 | 7.35 |
| CHEMBL365935 | — | — | 1 | 7.32 |
| CHEMBL371082 | — | — | 1 | 7.26 |
| CHEMBL114278 | — | — | 1 | 7.17 |
| CHEMBL363692 | — | — | 1 | 6.67 |
| CHEMBL111720 | — | — | 1 | 6.64 |
| CHEMBL191487 | — | — | 1 | 6.58 |
| CHEMBL190348 | — | — | 1 | 6.51 |
| CHEMBL322979 | — | — | 1 | 6.41 |
| CHEMBL190539 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113208 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL264770 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL191260 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL191130 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL371417 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL112598 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL33989 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL363286 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL190290 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL113331 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL370086 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL364630 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL189976 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL371182 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL365935 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL371082 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL114278 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL363692 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL111720 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL191487 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL190348 | — | Ki | = | 308.0 | nM | 6.51 |
| CHEMBL322979 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL190539 | — | Ki | = | 693.0 | nM | 6.16 |