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Assay Detail

CHEMBL830230

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for kappa opioid receptor of guinea pig cerebellum
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Cerebellum
Confidence 9 — Direct single protein target
Curated By Expert

Target

Kappa-type opioid receptor (CHEMBL3952)
Type SINGLE PROTEIN
Organism Cavia porcellus

Publication

Rationale, design, and synthesis of novel phenyl imidazoles as opioid receptor agonists for gastrointestinal disorders.
Breslin HJ, Miskowski TA, Rafferty BM, Coutinho SV, Palmer JM, Wallace NH, Schneider CR, Kimball ES, Zhang SP, Li J, Colburn RW, Stone DJ, Martinez RP, He W.
J Med Chem (2004) 47 : 5009 -5020
PubMed 15456245 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 6.91 6.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL361274 1 6.91

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL361274 Ki = 124.0 nM 6.91