Assay Detail
Binding
CHEMBL830236
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Binding affinity towards Melanocortin 4 receptor using [125I]NDP-MSH
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ".
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.54 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339053 | — | — | 2 | 10.30 |
| CHEMBL365039 | — | — | 2 | 9.00 |
| CHEMBL263182 | — | — | 1 | 6.41 |
| CHEMBL362670 | — | — | 1 | 6.07 |
| CHEMBL405150 | — | — | 1 | 6.00 |
| CHEMBL361052 | — | — | 1 | 5.85 |
| CHEMBL180937 | — | — | 1 | 5.82 |
| CHEMBL185195 | — | — | 1 | 4.52 |
| CHEMBL363757 | — | — | 1 | 4.24 |
| CHEMBL362010 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339053 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL365039 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL339053 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL365039 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL263182 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL362670 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL405150 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL361052 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL180937 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL185195 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL363757 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL362010 | — | Ki | = | 169000.0 | nM | - |