Assay Detail

CHEMBL830295

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Binding

Inhibition constant against rat cathepsin K

ChEMBL ↗

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Target

Cathepsin K (CHEMBL3034) ↗

Open DB target context

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Primary target Cathepsin K

CHEMBL3034

Anchored from Assay target.

Protein identity Cathepsin K

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Cathepsin K (CHEMBL3034) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Acyclic cyanamide-based inhibitors of cathepsin K.

Barrett DG, Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Payne JA, Shewchuk LM, Willard DH, Wright LL.
Bioorg Med Chem Lett (2005) 15 : 3039 -3043
PubMed 15896958 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	10.14	10.14

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL191558	—	—	1	10.14

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL191558	—	Ki	=	0.072	nM	10.14