Assay Detail
Binding
CHEMBL830377
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Binding affinity for human Histamine H1 receptor in CHO K1 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.11 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366925 | — | — | 1 | 8.30 |
| CHEMBL1000 | CETIRIZINE | 4.0 | 1 | 8.23 |
| CHEMBL179590 | — | — | 1 | 8.23 |
| CHEMBL181085 | — | — | 1 | 8.12 |
| CHEMBL180233 | — | — | 1 | 8.02 |
| CHEMBL360666 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366925 | — | Ki | = | 5.01 | nM | 8.30 |
| CHEMBL1000 | CETIRIZINE | Ki | = | 5.89 | nM | 8.23 |
| CHEMBL179590 | — | Ki | = | 5.89 | nM | 8.23 |
| CHEMBL181085 | — | Ki | = | 7.59 | nM | 8.12 |
| CHEMBL180233 | — | Ki | = | 9.55 | nM | 8.02 |
| CHEMBL360666 | — | Ki | = | 17.8 | nM | 7.75 |