Assay Detail
Binding
CHEMBL830383
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Inhibitory activity against human carbonic anhydrase I
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 6.85 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178403 | — | — | 1 | 7.62 |
| CHEMBL181082 | — | — | 1 | 7.62 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL181422 | — | — | 1 | 7.48 |
| CHEMBL178560 | — | — | 1 | 7.40 |
| CHEMBL180177 | THIOUREIDO SULFONAMIDE | — | 1 | 7.30 |
| CHEMBL180506 | — | — | 1 | 7.27 |
| CHEMBL538564 | — | — | 1 | 7.27 |
| CHEMBL182197 | — | — | 1 | 7.21 |
| CHEMBL181825 | — | — | 1 | 7.20 |
| CHEMBL182135 | — | — | 1 | 7.14 |
| CHEMBL360254 | — | — | 1 | 7.14 |
| CHEMBL180936 | — | — | 1 | 7.13 |
| CHEMBL179355 | — | — | 1 | 7.11 |
| CHEMBL181716 | — | — | 1 | 7.10 |
| CHEMBL362636 | — | — | 1 | 7.10 |
| CHEMBL361827 | — | — | 1 | 7.08 |
| CHEMBL361955 | — | — | 1 | 7.02 |
| CHEMBL179218 | — | — | 1 | 7.00 |
| CHEMBL178603 | — | — | 1 | 6.95 |
| CHEMBL413357 | — | — | 1 | 6.87 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL178664 | THIOUREIDO SULFONAMIDE | — | 1 | 6.60 |
| CHEMBL180675 | THIOUREIDO SULFONAMIDE | — | 1 | 6.50 |
| CHEMBL180195 | — | — | 1 | 6.49 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.11 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.92 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 4.55 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178403 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL181082 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL181422 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL178560 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL180177 | THIOUREIDO SULFONAMIDE | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL180506 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL538564 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL182197 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL181825 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL182135 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL360254 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL180936 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL179355 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL181716 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL362636 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL361827 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL361955 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL179218 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL178603 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL413357 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL178664 | THIOUREIDO SULFONAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL180675 | THIOUREIDO SULFONAMIDE | Ki | = | 313.0 | nM | 6.50 |
| CHEMBL180195 | — | Ki | = | 324.0 | nM | 6.49 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 50000.0 | nM | 4.30 |