Assay Detail
Binding
CHEMBL830387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CCPA from recombinant human adenosine A1 receptor expressed in CHO cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-Pyrazolyl-N(6)-substituted adenosine derivatives as high affinity and selective adenosine A(3) receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 5.80 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | — | 1 | 7.27 |
| CHEMBL375190 | — | — | 1 | 6.41 |
| CHEMBL363458 | — | — | 1 | 6.11 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 5.91 |
| CHEMBL359991 | — | — | 1 | 5.89 |
| CHEMBL231891 | — | — | 1 | 5.89 |
| CHEMBL574597 | — | — | 1 | 5.77 |
| CHEMBL186443 | — | — | 1 | 5.75 |
| CHEMBL184557 | — | — | 1 | 5.70 |
| CHEMBL361072 | — | — | 1 | 5.58 |
| CHEMBL188482 | — | — | 1 | 5.52 |
| CHEMBL400414 | — | — | 1 | 5.43 |
| CHEMBL361938 | — | — | 1 | 5.42 |
| CHEMBL398587 | — | — | 1 | 5.42 |
| CHEMBL362117 | — | — | 1 | 5.38 |
| CHEMBL361075 | — | — | 1 | 5.35 |
| CHEMBL231677 | — | — | 1 | - |
| CHEMBL365642 | — | — | 1 | - |
| CHEMBL189069 | — | — | 1 | - |
| CHEMBL183940 | — | — | 1 | - |
| CHEMBL234790 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119709 | IB-MECA | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL375190 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL363458 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 1240.0 | nM | 5.91 |
| CHEMBL359991 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL231891 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL574597 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL186443 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL184557 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL361072 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL188482 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL400414 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL361938 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL398587 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL362117 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL361075 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL231677 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL365642 | — | Ki | > | 6000.0 | nM | - |
| CHEMBL189069 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL183940 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL234790 | — | Ki | > | 6000.0 | nM | - |