Assay Detail
Binding
CHEMBL830409
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Inhibition of [3H]SQ-29,548 binding to human Thromboxane A2 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.71 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361812 | RAMATROBAN | 4.0 | 1 | 8.35 |
| CHEMBL194085 | — | — | 1 | 6.27 |
| CHEMBL373118 | — | — | 1 | 5.52 |
| CHEMBL179036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361812 | RAMATROBAN | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL194085 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL373118 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL179036 | — | Ki | > | 10000.0 | nM | - |