Assay Detail
Binding
CHEMBL830430
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Ability to inhibit the binding of [3H]PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP3
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL4336) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of orally active prostaglandin D2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 5.78 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184684 | — | — | 1 | 6.12 |
| CHEMBL363984 | — | — | 1 | 6.01 |
| CHEMBL365243 | — | — | 1 | 5.92 |
| CHEMBL364841 | — | — | 1 | 5.77 |
| CHEMBL185251 | — | — | 1 | 5.77 |
| CHEMBL361457 | — | — | 1 | 5.66 |
| CHEMBL182555 | — | — | 1 | 5.48 |
| CHEMBL186925 | — | — | 1 | 5.48 |
| CHEMBL365908 | — | — | 1 | - |
| CHEMBL365696 | — | — | 1 | - |
| CHEMBL186735 | — | — | 1 | - |
| CHEMBL365829 | — | — | 1 | - |
| CHEMBL359564 | — | — | 1 | - |
| CHEMBL364593 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184684 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL363984 | — | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL365243 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL364841 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL185251 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL361457 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL182555 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL186925 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL365908 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL365696 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL186735 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL365829 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL359564 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL364593 | — | Ki | > | 10000.0 | nM | - |