Assay Detail
Binding
CHEMBL830433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]SQ-29,548 binding to thromboxane A2 receptors (TP) of human platelet membrane
23
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.44 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190288 | — | — | 1 | 8.37 |
| CHEMBL190236 | — | — | 1 | 8.35 |
| CHEMBL191056 | — | — | 1 | 7.58 |
| CHEMBL365501 | — | — | 1 | 7.29 |
| CHEMBL190840 | — | — | 1 | 7.14 |
| CHEMBL192662 | — | — | 1 | 7.11 |
| CHEMBL190708 | — | — | 1 | 7.06 |
| CHEMBL191118 | — | — | 1 | 6.82 |
| CHEMBL189694 | — | — | 1 | 6.75 |
| CHEMBL188384 | — | — | 1 | 6.51 |
| CHEMBL187544 | — | — | 1 | 5.60 |
| CHEMBL361939 | — | — | 5 | 5.51 |
| CHEMBL187758 | — | — | 1 | 5.51 |
| CHEMBL189063 | — | — | 1 | 5.51 |
| CHEMBL192661 | — | — | 1 | 5.29 |
| CHEMBL190735 | — | — | 1 | - |
| CHEMBL188758 | — | — | 1 | - |
| CHEMBL191175 | — | — | 1 | - |
| CHEMBL191162 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190288 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL190236 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL191056 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL365501 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL190840 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL192662 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL190708 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL191118 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL189694 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL188384 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL187544 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL187758 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL189063 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL361939 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL361939 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL361939 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL361939 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL361939 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL192661 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL188758 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL191175 | — | Ki | > | 15000.0 | nM | - |
| CHEMBL190735 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL191162 | — | Ki | > | 5900.0 | nM | - |