Assay Detail
Binding
CHEMBL830441
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]granisetron from 5-hydroxytryptamine 3 receptor of rat cortical membrane
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 8.89 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439857 | — | — | 1 | 10.10 |
| CHEMBL191035 | — | — | 1 | 9.96 |
| CHEMBL195881 | — | — | 1 | 9.77 |
| CHEMBL192675 | — | — | 1 | 9.68 |
| CHEMBL43355 | — | — | 1 | 9.64 |
| CHEMBL64078 | — | — | 1 | 9.62 |
| CHEMBL289469 | GRANISETRON | 4.0 | 1 | 9.46 |
| CHEMBL364501 | — | — | 1 | 9.43 |
| CHEMBL191036 | — | — | 1 | 9.39 |
| CHEMBL372262 | — | — | 1 | 9.37 |
| CHEMBL191900 | — | — | 1 | 9.35 |
| CHEMBL363595 | — | — | 1 | 9.29 |
| CHEMBL191084 | — | — | 1 | 9.26 |
| CHEMBL371144 | — | — | 1 | 9.25 |
| CHEMBL192869 | — | — | 1 | 9.17 |
| CHEMBL192220 | — | — | 1 | 9.11 |
| CHEMBL192794 | — | — | 1 | 9.08 |
| CHEMBL192930 | — | — | 1 | 9.07 |
| CHEMBL193318 | — | — | 1 | 9.04 |
| CHEMBL194492 | — | — | 1 | 8.96 |
| CHEMBL195056 | — | — | 1 | 8.92 |
| CHEMBL195498 | — | — | 1 | 8.80 |
| CHEMBL193460 | — | — | 1 | 8.80 |
| CHEMBL191649 | — | — | 1 | 8.68 |
| CHEMBL192611 | — | — | 1 | 8.66 |
| CHEMBL195490 | — | — | 1 | 8.62 |
| CHEMBL364895 | — | — | 1 | 8.57 |
| CHEMBL191707 | — | — | 1 | 8.52 |
| CHEMBL195902 | — | — | 1 | 8.44 |
| CHEMBL364957 | — | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439857 | — | Ki | = | 0.08 | nM | 10.10 |
| CHEMBL191035 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL195881 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL192675 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL43355 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL64078 | — | Ki | = | 0.24 | nM | 9.62 |
| CHEMBL289469 | GRANISETRON | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL364501 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL191036 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL372262 | — | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL191900 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL363595 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL191084 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL371144 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL192869 | — | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL192220 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL192794 | — | Ki | = | 0.84 | nM | 9.08 |
| CHEMBL192930 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL193318 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL194492 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL195056 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL195498 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL193460 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL191649 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL192611 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL195490 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL364895 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL191707 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL195902 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL364957 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL195241 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL192350 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL372203 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL191458 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL365180 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL436287 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL191763 | — | Ki | = | 188.0 | nM | 6.73 |