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Assay Detail

CHEMBL830845

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Binding
Inhibitory concentration for Cyclooxygenase-1 (Prostaglandin G/H synthase 1) in human whole blood
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Tissue Blood
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prostaglandin G/H synthase 1 (CHEMBL221)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

QSAR studies on structurally similar 2-(4-methanesulfonylphenyl)pyran-4-ones as selective COX-2 inhibitors: a Hansch approach.
Prasanna S, Manivannan E, Chaturvedi SC.
Bioorg Med Chem Lett (2005) 15 : 313 -320
PubMed 15603946 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.66 5.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL341320 1 5.16
CHEMBL126369 1 4.86
CHEMBL127153 1 4.78
CHEMBL442767 1 4.73
CHEMBL129640 1 4.67
CHEMBL127211 1 4.65
CHEMBL126303 1 4.64
CHEMBL125460 1 4.64
CHEMBL338457 1 4.45
CHEMBL126991 1 4.44
CHEMBL127190 1 4.43
CHEMBL127868 1 4.41
CHEMBL420351 1 -
CHEMBL127514 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL341320 IC50 = 6902.4 nM 5.16
CHEMBL126369 IC50 = 13699.35 nM 4.86
CHEMBL127153 IC50 = 16595.87 nM 4.78
CHEMBL442767 IC50 = 18801.82 nM 4.73
CHEMBL129640 IC50 = 21198.25 nM 4.67
CHEMBL127211 IC50 = 22299.75 nM 4.65
CHEMBL126303 IC50 = 22803.42 nM 4.64
CHEMBL125460 IC50 = 22803.42 nM 4.64
CHEMBL338457 IC50 = 35196.54 nM 4.45
CHEMBL126991 IC50 = 36559.48 nM 4.44
CHEMBL127190 IC50 = 37068.07 nM 4.43
CHEMBL127868 IC50 = 39003.18 nM 4.41
CHEMBL420351 IC50 = 207014.13 nM -
CHEMBL127514 IC50 = 119014.53 nM -