Assay Detail
Binding
CHEMBL830860
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against porcine ALR1 Aldehyde reductase using DL-glyceraldehyde
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member A1 (CHEMBL4049) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.25 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | 2.0 | 1 | 5.60 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 5.40 |
| CHEMBL84060 | (R,S)-FIDARESTAT | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL266497 | SORBINIL | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL84060 | (R,S)-FIDARESTAT | IC50 | = | 17800.0 | nM | 4.75 |