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Assay Detail

CHEMBL830897

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Binding
Inhibitory concentration against rabbit reticulocyte 15-lipoxygenase with substrate arachidonic acid
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL4358) ↗
Type SINGLE PROTEIN
Organism Oryctolagus cuniculus

Publication

Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.
Weinstein DS, Liu W, Gu Z, Langevine C, Ngu K, Fadnis L, Combs DW, Sitkoff D, Ahmad S, Zhuang S, Chen X, Wang FL, Loughney DA, Atwal KS, Zahler R, Macor JE, Madsen CS, Murugesan N.
Bioorg Med Chem Lett (2005) 15 : 1435 -1440
PubMed 15713402 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 48 6.61 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL178139 — — 1 7.85
CHEMBL426423 — — 1 7.77
CHEMBL179335 — — 1 7.68
CHEMBL362689 — — 1 7.58
CHEMBL180052 — — 1 7.47
CHEMBL181226 — — 1 7.38
CHEMBL179959 — — 1 7.38
CHEMBL369336 — — 1 7.33
CHEMBL178920 — — 1 7.30
CHEMBL361315 — — 1 7.29
CHEMBL368254 — — 1 7.24
CHEMBL3706765 — — 1 7.15
CHEMBL178613 — — 1 7.11
CHEMBL180838 — — 1 6.95
CHEMBL181409 — — 1 6.92
CHEMBL362645 — — 1 6.88
CHEMBL180769 — — 1 6.87
CHEMBL178178 — — 1 6.85
CHEMBL360042 — — 1 6.85
CHEMBL433557 — — 1 6.79
CHEMBL178575 — — 1 6.79
CHEMBL178611 — — 1 6.77
CHEMBL427319 — — 1 6.75
CHEMBL181128 — — 1 6.70
CHEMBL361639 — — 1 6.64
CHEMBL181220 — — 1 6.61
CHEMBL360987 — — 1 6.50
CHEMBL360161 — — 1 6.48
CHEMBL425336 — — 1 6.47
CHEMBL181837 — — 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL178139 — IC50 = 14.0 nM 7.85
CHEMBL426423 — IC50 = 17.0 nM 7.77
CHEMBL179335 — IC50 = 21.0 nM 7.68
CHEMBL362689 — IC50 = 26.0 nM 7.58
CHEMBL180052 — IC50 = 34.0 nM 7.47
CHEMBL181226 — IC50 = 42.0 nM 7.38
CHEMBL179959 — IC50 = 42.0 nM 7.38
CHEMBL369336 — IC50 = 47.0 nM 7.33
CHEMBL178920 — IC50 = 50.0 nM 7.30
CHEMBL361315 — IC50 = 51.0 nM 7.29
CHEMBL368254 — IC50 = 58.0 nM 7.24
CHEMBL3706765 — IC50 = 71.0 nM 7.15
CHEMBL178613 — IC50 = 78.0 nM 7.11
CHEMBL180838 — IC50 = 112.0 nM 6.95
CHEMBL181409 — IC50 = 120.0 nM 6.92
CHEMBL362645 — IC50 = 132.0 nM 6.88
CHEMBL180769 — IC50 = 135.0 nM 6.87
CHEMBL178178 — IC50 = 140.0 nM 6.85
CHEMBL360042 — IC50 = 140.0 nM 6.85
CHEMBL433557 — IC50 = 164.0 nM 6.79
CHEMBL178575 — IC50 = 161.0 nM 6.79
CHEMBL178611 — IC50 = 170.0 nM 6.77
CHEMBL427319 — IC50 = 179.0 nM 6.75
CHEMBL181128 — IC50 = 200.0 nM 6.70
CHEMBL361639 — IC50 = 230.0 nM 6.64
CHEMBL181220 — IC50 = 247.0 nM 6.61
CHEMBL360987 — IC50 = 320.0 nM 6.50
CHEMBL360161 — IC50 = 330.0 nM 6.48
CHEMBL425336 — IC50 = 340.0 nM 6.47
CHEMBL181837 — IC50 = 382.0 nM 6.42
CHEMBL178495 — IC50 = 460.0 nM 6.34
CHEMBL369787 — IC50 = 472.0 nM 6.33
CHEMBL181292 — IC50 = 470.0 nM 6.33
CHEMBL180256 — IC50 = 730.0 nM 6.14
CHEMBL181028 — IC50 = 780.0 nM 6.11
CHEMBL181743 — IC50 = 1020.0 nM 5.99
CHEMBL180979 — IC50 = 1090.0 nM 5.96
CHEMBL263232 — IC50 = 1420.0 nM 5.85
CHEMBL180636 — IC50 = 2900.0 nM 5.54
CHEMBL179844 — IC50 = 3200.0 nM 5.50
CHEMBL179990 — IC50 = 3900.0 nM 5.41
CHEMBL360890 — IC50 = 4000.0 nM 5.40
CHEMBL425695 — IC50 = 4050.0 nM 5.39
CHEMBL433554 — IC50 = 4200.0 nM 5.38
CHEMBL181253 — IC50 = 6300.0 nM 5.20
CHEMBL180783 — IC50 > 10000.0 nM -
CHEMBL181939 — IC50 > 10000.0 nM -
CHEMBL181340 — IC50 > 30000.0 nM -