Assay Detail
Binding
CHEMBL830957
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat liver dihydrofolate reductase
177
Total Activities
172
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 177 | 6.59 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23532 | — | — | 1 | 8.68 |
| CHEMBL57624 | — | — | 1 | 8.57 |
| CHEMBL55727 | — | — | 1 | 8.14 |
| CHEMBL54538 | — | — | 1 | 8.14 |
| CHEMBL50514 | — | — | 1 | 8.12 |
| CHEMBL283518 | — | — | 1 | 8.12 |
| CHEMBL113816 | — | — | 1 | 8.09 |
| CHEMBL52433 | — | — | 1 | 7.98 |
| CHEMBL49454 | — | — | 1 | 7.93 |
| CHEMBL264386 | — | — | 1 | 7.89 |
| CHEMBL299174 | — | — | 1 | 7.80 |
| CHEMBL300603 | — | — | 1 | 7.77 |
| CHEMBL367802 | — | — | 1 | 7.77 |
| CHEMBL279679 | — | — | 1 | 7.76 |
| CHEMBL53693 | — | — | 1 | 7.76 |
| CHEMBL415962 | — | — | 1 | 7.75 |
| CHEMBL179319 | — | — | 1 | 7.75 |
| CHEMBL137981 | — | — | 1 | 7.75 |
| CHEMBL117750 | — | — | 1 | 7.72 |
| CHEMBL55063 | — | — | 1 | 7.62 |
| CHEMBL310880 | — | — | 2 | 7.58 |
| CHEMBL325434 | — | — | 1 | 7.58 |
| CHEMBL23867 | — | — | 1 | 7.53 |
| CHEMBL35222 | — | — | 1 | 7.52 |
| CHEMBL420224 | — | — | 1 | 7.48 |
| CHEMBL32190 | — | — | 1 | 7.48 |
| CHEMBL121433 | — | — | 1 | 7.47 |
| CHEMBL54792 | — | — | 1 | 7.46 |
| CHEMBL80065 | — | — | 1 | 7.46 |
| CHEMBL79347 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23532 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL57624 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL55727 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL54538 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL283518 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL50514 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL113816 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL52433 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL49454 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL264386 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL299174 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL300603 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL367802 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL53693 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL279679 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL179319 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL137981 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL415962 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL117750 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL55063 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL310880 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL325434 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL23867 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL35222 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL420224 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL32190 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL121433 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL80065 | — | IC50 | = | 34.9 | nM | 7.46 |
| CHEMBL54792 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL79347 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL80066 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL299140 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL82975 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL115804 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL23569 | — | IC50 | = | 42.5 | nM | 7.37 |
| CHEMBL53420 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL279680 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL123122 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL55191 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL121348 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL445359 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL301105 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL23416 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL52688 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL81820 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL53903 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL292427 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL312348 | — | IC50 | = | 55.6 | nM | 7.25 |
| CHEMBL32113 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL54732 | — | IC50 | = | 58.0 | nM | 7.24 |