Assay Detail
Binding
CHEMBL830958
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Inhibitory concentration against growth factor receptor bound protein 2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Growth factor receptor-bound protein 2 (CHEMBL3663) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.05 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191728 | — | — | 1 | 8.48 |
| CHEMBL424823 | — | — | 1 | 8.20 |
| CHEMBL193281 | — | — | 1 | 8.08 |
| CHEMBL263328 | — | — | 1 | 8.06 |
| CHEMBL349373 | — | — | 1 | 7.82 |
| CHEMBL193015 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191728 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL424823 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL193281 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL263328 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL349373 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL193015 | — | IC50 | = | 22.5 | nM | 7.65 |