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Assay Detail

CHEMBL830965

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Binding
Inhibitory concentration against acetylcholinesterase from rat cortex homogenate by ellman method was determined
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Acetylcholinesterase (CHEMBL3199)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B.
Feng S, Xia Y, Han D, Zheng C, He X, Tang X, Bai D.
Bioorg Med Chem Lett (2005) 15 : 523 -526
PubMed 15664805 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.14 6.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL395283 1 6.94
CHEMBL389583 1 6.66
CHEMBL2113015 1 6.39
CHEMBL244870 1 5.93
CHEMBL2113014 1 5.25
CHEMBL2113011 1 5.24
CHEMBL2113013 1 5.21
CHEMBL183649 1 5.09
CHEMBL368912 1 5.02
CHEMBL2310903 1 4.99
CHEMBL183130 1 4.68
CHEMBL2113016 1 4.63
CHEMBL182212 1 4.57
CHEMBL2310904 1 4.50
CHEMBL2113010 1 4.48
CHEMBL2310905 1 4.42
CHEMBL359698 1 4.29
CHEMBL361866 1 4.18
CHEMBL181690 1 -
CHEMBL362433 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL395283 IC50 = 114.0 nM 6.94
CHEMBL389583 IC50 = 218.0 nM 6.66
CHEMBL2113015 IC50 = 407.0 nM 6.39
CHEMBL244870 IC50 = 1173.0 nM 5.93
CHEMBL2113014 IC50 = 5580.0 nM 5.25
CHEMBL2113011 IC50 = 5747.0 nM 5.24
CHEMBL2113013 IC50 = 6190.0 nM 5.21
CHEMBL183649 IC50 = 8202.0 nM 5.09
CHEMBL368912 IC50 = 9531.0 nM 5.02
CHEMBL2310903 IC50 = 10297.0 nM 4.99
CHEMBL183130 IC50 = 20700.0 nM 4.68
CHEMBL2113016 IC50 = 23500.0 nM 4.63
CHEMBL182212 IC50 = 26700.0 nM 4.57
CHEMBL2310904 IC50 = 31600.0 nM 4.50
CHEMBL2113010 IC50 = 33300.0 nM 4.48
CHEMBL2310905 IC50 = 38100.0 nM 4.42
CHEMBL359698 IC50 = 50700.0 nM 4.29
CHEMBL361866 IC50 = 66450.0 nM 4.18
CHEMBL181690 IC50 > 52000.0 nM -
CHEMBL362433 IC50 > 54000.0 nM -