Assay Detail
Binding
CHEMBL830991
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In vitro inhibitory concentration against Prostaglandin G/H synthase 2 in human whole blood assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.89 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.24 |
| CHEMBL361504 | — | — | 1 | 5.83 |
| CHEMBL365033 | — | — | 1 | 5.60 |
| CHEMBL442224 | — | — | 1 | - |
| CHEMBL363228 | — | — | 1 | - |
| CHEMBL186764 | — | — | 1 | - |
| CHEMBL188739 | — | — | 1 | - |
| CHEMBL185638 | — | — | 1 | - |
| CHEMBL185639 | — | — | 1 | - |
| CHEMBL186817 | — | — | 1 | - |
| CHEMBL189701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL865 | VALDECOXIB | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL361504 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL365033 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL442224 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL363228 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL186764 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL188739 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL185638 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL185639 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL186817 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL189701 | — | IC50 | > | 100000.0 | nM | - |