Assay Detail
Binding
CHEMBL831071
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Binding potency for human ER alpha
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 7: Dihydrobenzoxathiin SERAMs with bicyclic amine side chains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 9.12 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433769 | — | — | 1 | 9.52 |
| CHEMBL185083 | — | — | 1 | 9.40 |
| CHEMBL181862 | — | — | 1 | 9.30 |
| CHEMBL184367 | — | — | 1 | 9.22 |
| CHEMBL184421 | — | — | 1 | 9.22 |
| CHEMBL184371 | — | — | 1 | 9.22 |
| CHEMBL184360 | — | — | 1 | 9.22 |
| CHEMBL184202 | — | — | 1 | 9.15 |
| CHEMBL434525 | — | — | 1 | 9.15 |
| CHEMBL184598 | — | — | 1 | 9.10 |
| CHEMBL304552 | — | — | 1 | 9.10 |
| CHEMBL368688 | — | — | 1 | 9.05 |
| CHEMBL185231 | — | — | 1 | 9.00 |
| CHEMBL184974 | — | — | 1 | 8.92 |
| CHEMBL361056 | — | — | 1 | 8.89 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.89 |
| CHEMBL81 | RALOXIFENE | 4.0 | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433769 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL185083 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL181862 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL184367 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL184421 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL184371 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL184360 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL184202 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL434525 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL184598 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL304552 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL368688 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL185231 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL184974 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL361056 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL81 | RALOXIFENE | IC50 | = | 1.8 | nM | 8.74 |