Assay Detail
Binding
CHEMBL831075
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against rat ALR2 aldose reductase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.58 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | 2.0 | 1 | 7.46 |
| CHEMBL84060 | (R,S)-FIDARESTAT | — | 1 | 6.24 |
| CHEMBL266497 | SORBINIL | 3.0 | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84446 | FIDARESTAT | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL84060 | (R,S)-FIDARESTAT | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL266497 | SORBINIL | IC50 | = | 900.0 | nM | 6.05 |