Assay Detail
Binding
CHEMBL831077
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Inhibition of estrogen receptor alpha
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Estrogen receptor ligands. Part 10: Chromanes: old scaffolds for new SERAMs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 8.80 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181368 | — | — | 1 | 9.52 |
| CHEMBL359633 | — | — | 1 | 9.30 |
| CHEMBL362428 | — | — | 1 | 9.18 |
| CHEMBL181248 | — | — | 1 | 9.15 |
| CHEMBL304552 | — | — | 1 | 9.10 |
| CHEMBL181404 | — | — | 1 | 9.10 |
| CHEMBL180146 | — | — | 1 | 9.10 |
| CHEMBL361005 | — | — | 1 | 9.10 |
| CHEMBL181369 | — | — | 1 | 9.05 |
| CHEMBL180995 | — | — | 1 | 9.05 |
| CHEMBL433581 | — | — | 1 | 8.89 |
| CHEMBL368449 | — | — | 1 | 8.89 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.89 |
| CHEMBL360315 | — | — | 1 | 8.85 |
| CHEMBL178470 | — | — | 1 | 8.85 |
| CHEMBL181936 | — | — | 1 | 8.82 |
| CHEMBL2113002 | — | — | 1 | 8.82 |
| CHEMBL369724 | — | — | 1 | 8.62 |
| CHEMBL359671 | — | — | 1 | 8.60 |
| CHEMBL178559 | — | — | 1 | 7.85 |
| CHEMBL180253 | — | — | 1 | 7.42 |
| CHEMBL180538 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181368 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL359633 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL362428 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL181248 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL304552 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL181404 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL180146 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL361005 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL181369 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL180995 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL433581 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL368449 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL360315 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL178470 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL181936 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2113002 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL369724 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL359671 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL178559 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL180253 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL180538 | — | IC50 | = | 45.0 | nM | 7.35 |