Assay Detail
Binding
CHEMBL831078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect on human reticulocyte 15-lipoxygenase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL2903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.49 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185893 | — | — | 1 | 6.96 |
| CHEMBL185753 | SPONGIADIOXIN C | — | 1 | 6.10 |
| CHEMBL150098 | — | — | 1 | 6.10 |
| CHEMBL185828 | SPONGIADIOXIN A | — | 1 | 6.05 |
| CHEMBL362761 | — | — | 1 | 5.75 |
| CHEMBL186752 | — | — | 1 | 5.70 |
| CHEMBL148503 | — | — | 1 | 5.66 |
| CHEMBL360190 | BASTADIN 7 | — | 1 | 5.40 |
| CHEMBL184450 | — | — | 1 | 5.40 |
| CHEMBL186098 | — | — | 1 | 5.30 |
| CHEMBL184398 | — | — | 1 | 5.30 |
| CHEMBL186099 | — | — | 1 | 5.00 |
| CHEMBL187472 | — | — | 1 | 4.96 |
| CHEMBL186858 | — | — | 1 | 4.47 |
| CHEMBL57284 | — | — | 1 | 4.26 |
| CHEMBL186007 | — | — | 1 | - |
| CHEMBL111507 | — | — | 1 | - |
| CHEMBL187292 | — | — | 1 | - |
| CHEMBL184410 | — | — | 1 | - |
| CHEMBL185651 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185893 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL185753 | SPONGIADIOXIN C | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL150098 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL185828 | SPONGIADIOXIN A | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL362761 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL186752 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL148503 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL360190 | BASTADIN 7 | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL184450 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL186098 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL184398 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL186099 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL187472 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL186858 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL57284 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL186007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL111507 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL187292 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL184410 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL185651 | — | IC50 | > | 100000.0 | nM | - |