Assay Detail
Binding
CHEMBL831083
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Concentration required to inhibit quorum sensor of Staphylococcus aureus
23
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Receptor-histidine kinase AgrC (CHEMBL4726) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus |
Publication
Virulence regulation and quorum sensing in staphylococcal infections: competitive AgrC antagonists as quorum sensing inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.65 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182114 | — | — | 4 | 10.00 |
| CHEMBL362838 | — | — | 4 | 9.52 |
| CHEMBL359961 | — | — | 4 | 9.52 |
| CHEMBL2371770 | — | — | 2 | 8.55 |
| CHEMBL262285 | — | — | 2 | 7.75 |
| CHEMBL3085536 | — | — | 2 | 7.72 |
| CHEMBL182551 | — | — | 2 | 7.52 |
| CHEMBL369309 | — | — | 2 | 6.62 |
| CHEMBL362839 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182114 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL362838 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL359961 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2371770 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL362838 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL182114 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL182114 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL182114 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL362838 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL359961 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL359961 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL262285 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3085536 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL362838 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL182551 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2371770 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL359961 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL369309 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL182551 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL3085536 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL262285 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL369309 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL362839 | — | IC50 | = | 8000.0 | nM | 5.10 |