Assay Detail
Binding
CHEMBL831159
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Inhibition of human glucocorticoid receptor alpha by displacement of [3H]dexamethasone
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.22 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310570 | — | — | 1 | 9.10 |
| CHEMBL372684 | — | — | 1 | 8.82 |
| CHEMBL313062 | — | — | 1 | 8.72 |
| CHEMBL371376 | — | — | 1 | 8.54 |
| CHEMBL82546 | — | — | 1 | 8.34 |
| CHEMBL363179 | — | — | 1 | 8.29 |
| CHEMBL79807 | — | — | 1 | 8.28 |
| CHEMBL196347 | — | — | 1 | 8.15 |
| CHEMBL193404 | — | — | 1 | 8.12 |
| CHEMBL364015 | — | — | 1 | 8.04 |
| CHEMBL194077 | — | — | 1 | 7.99 |
| CHEMBL362914 | — | — | 1 | 7.87 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 7.86 |
| CHEMBL365818 | — | — | 1 | 7.63 |
| CHEMBL195972 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310570 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL372684 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL313062 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL371376 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL82546 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL363179 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL79807 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL196347 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL193404 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL364015 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL194077 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL362914 | — | IC50 | = | 13.6 | nM | 7.87 |
| CHEMBL131 | PREDNISOLONE | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL365818 | — | IC50 | = | 23.2 | nM | 7.63 |
| CHEMBL195972 | — | IC50 | = | 29.1 | nM | 7.54 |