Assay Detail
Binding
CHEMBL831381
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Inhibitory concentration against human sodium/hydrogen exchanger (NHE-1) in PS120 variant cells
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.71 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL196715 | — | — | 1 | 6.77 |
| CHEMBL197401 | — | — | 1 | 6.70 |
| CHEMBL195422 | — | — | 1 | 6.70 |
| CHEMBL196790 | — | — | 1 | 6.57 |
| CHEMBL425378 | — | — | 1 | 6.51 |
| CHEMBL197519 | — | — | 1 | 6.40 |
| CHEMBL196487 | — | — | 1 | 6.32 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 6.17 |
| CHEMBL425565 | — | — | 1 | 6.17 |
| CHEMBL193812 | — | — | 1 | 6.07 |
| CHEMBL196714 | — | — | 1 | 5.77 |
| CHEMBL371454 | — | — | 1 | 5.70 |
| CHEMBL197156 | — | — | 1 | 5.64 |
| CHEMBL193701 | — | — | 1 | 5.60 |
| CHEMBL193499 | — | — | 1 | 5.60 |
| CHEMBL197155 | — | — | 1 | 5.47 |
| CHEMBL372839 | — | — | 1 | 5.47 |
| CHEMBL197409 | — | — | 1 | 5.41 |
| CHEMBL370216 | — | — | 1 | 5.38 |
| CHEMBL195986 | — | — | 1 | 5.36 |
| CHEMBL263960 | — | — | 1 | 5.29 |
| CHEMBL436285 | — | — | 1 | 5.25 |
| CHEMBL196655 | — | — | 1 | 5.11 |
| CHEMBL197147 | — | — | 1 | 5.08 |
| CHEMBL195507 | — | — | 1 | 5.07 |
| CHEMBL196066 | — | — | 1 | 5.05 |
| CHEMBL196943 | — | — | 1 | 4.96 |
| CHEMBL193941 | — | — | 1 | 4.96 |
| CHEMBL196645 | — | — | 1 | 4.92 |
| CHEMBL372360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL196715 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL197401 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL195422 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL196790 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL425378 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL197519 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL196487 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL425565 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL193812 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL196714 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL371454 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL197156 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL193701 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL193499 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL372839 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL197155 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL197409 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL370216 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL195986 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL263960 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL436285 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL196655 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL197147 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL195507 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL196066 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL196943 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL193941 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL196645 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL372360 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL194606 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL427551 | — | IC50 | > | 30000.0 | nM | - |