Assay Detail
Binding
CHEMBL831577
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Inhibition of Cyclin B-cyclin-dependent kinase 1
19
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.95 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261720 | — | — | 2 | 9.22 |
| CHEMBL361900 | — | — | 1 | 8.68 |
| CHEMBL363607 | — | — | 2 | 8.52 |
| CHEMBL425720 | — | — | 1 | 8.49 |
| CHEMBL187395 | — | — | 1 | 8.49 |
| CHEMBL364927 | — | — | 1 | 8.49 |
| CHEMBL370698 | — | — | 1 | 8.43 |
| CHEMBL190643 | — | — | 1 | 8.35 |
| CHEMBL363130 | — | — | 1 | 8.32 |
| CHEMBL191003 | JNJ-7706621 | — | 2 | 8.22 |
| CHEMBL189855 | — | — | 1 | 7.35 |
| CHEMBL190453 | — | — | 1 | 6.89 |
| CHEMBL190955 | — | — | 1 | 6.27 |
| CHEMBL189894 | — | — | 1 | 6.18 |
| CHEMBL190171 | — | — | 1 | 5.68 |
| CHEMBL187345 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261720 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL261720 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL361900 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL363607 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL187395 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL364927 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL425720 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL370698 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL190643 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL363130 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL191003 | JNJ-7706621 | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL363607 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL189855 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL190453 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL190955 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL189894 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL190171 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL187345 | — | IC50 | > | 100000.0 | nM | - |