Assay Detail
Binding
CHEMBL831661
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Inhibition of binding to human estrogen receptor alpha
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
QSAR of estrogen receptor modulators: exploring selectivity requirements for ER(alpha) versus ER(beta) binding of tetrahydroisoquinoline derivatives using E-state and physicochemical parameters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.41 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101382 | — | — | 1 | 7.72 |
| CHEMBL316080 | — | — | 1 | 7.68 |
| CHEMBL100763 | — | — | 1 | 7.57 |
| CHEMBL174502 | — | — | 1 | 7.55 |
| CHEMBL101807 | — | — | 1 | 7.54 |
| CHEMBL327515 | — | — | 1 | 7.51 |
| CHEMBL328388 | — | — | 1 | 7.51 |
| CHEMBL101997 | — | — | 1 | 7.51 |
| CHEMBL100617 | — | — | 1 | 7.47 |
| CHEMBL103294 | — | — | 1 | 7.46 |
| CHEMBL101083 | — | — | 1 | 7.42 |
| CHEMBL319211 | — | — | 1 | 7.41 |
| CHEMBL98558 | — | — | 1 | 7.40 |
| CHEMBL98470 | — | — | 1 | 7.36 |
| CHEMBL100595 | — | — | 1 | 7.34 |
| CHEMBL103305 | — | — | 1 | 7.31 |
| CHEMBL328810 | — | — | 1 | 7.25 |
| CHEMBL319678 | — | — | 1 | 7.18 |
| CHEMBL100231 | — | — | 1 | 7.15 |
| CHEMBL434346 | — | — | 1 | 7.15 |
| CHEMBL323119 | — | — | 1 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101382 | — | IC50 | = | 19.01 | nM | 7.72 |
| CHEMBL316080 | — | IC50 | = | 20.99 | nM | 7.68 |
| CHEMBL100763 | — | IC50 | = | 26.98 | nM | 7.57 |
| CHEMBL174502 | — | IC50 | = | 27.99 | nM | 7.55 |
| CHEMBL101807 | — | IC50 | = | 28.97 | nM | 7.54 |
| CHEMBL327515 | — | IC50 | = | 30.97 | nM | 7.51 |
| CHEMBL328388 | — | IC50 | = | 30.97 | nM | 7.51 |
| CHEMBL101997 | — | IC50 | = | 30.97 | nM | 7.51 |
| CHEMBL100617 | — | IC50 | = | 33.96 | nM | 7.47 |
| CHEMBL103294 | — | IC50 | = | 34.99 | nM | 7.46 |
| CHEMBL101083 | — | IC50 | = | 38.02 | nM | 7.42 |
| CHEMBL319211 | — | IC50 | = | 38.99 | nM | 7.41 |
| CHEMBL98558 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL98470 | — | IC50 | = | 43.95 | nM | 7.36 |
| CHEMBL100595 | — | IC50 | = | 46.03 | nM | 7.34 |
| CHEMBL103305 | — | IC50 | = | 48.98 | nM | 7.31 |
| CHEMBL328810 | — | IC50 | = | 55.98 | nM | 7.25 |
| CHEMBL319678 | — | IC50 | = | 66.07 | nM | 7.18 |
| CHEMBL100231 | — | IC50 | = | 70.96 | nM | 7.15 |
| CHEMBL434346 | — | IC50 | = | 70.96 | nM | 7.15 |
| CHEMBL323119 | — | IC50 | = | 93.97 | nM | 7.03 |