Assay Detail
Binding
CHEMBL831677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Neuronal nitric oxide synthase
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.58 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185024 | — | — | 1 | 7.10 |
| CHEMBL185584 | — | — | 1 | 6.89 |
| CHEMBL363477 | — | — | 1 | 6.85 |
| CHEMBL365849 | — | — | 1 | 6.51 |
| CHEMBL184798 | — | — | 1 | 6.21 |
| CHEMBL185161 | — | — | 1 | 6.21 |
| CHEMBL185441 | — | — | 1 | 6.18 |
| CHEMBL183012 | — | — | 1 | 6.10 |
| CHEMBL359703 | — | — | 1 | 6.05 |
| CHEMBL362148 | — | — | 1 | 5.75 |
| CHEMBL185585 | — | — | 1 | 5.62 |
| CHEMBL360616 | — | — | 1 | 5.58 |
| CHEMBL182305 | — | — | 1 | 5.51 |
| CHEMBL186142 | — | — | 1 | 5.32 |
| CHEMBL161318 | — | — | 1 | 5.02 |
| CHEMBL185535 | — | — | 1 | 5.02 |
| CHEMBL361419 | — | — | 1 | 5.00 |
| CHEMBL365637 | — | — | 1 | 4.97 |
| CHEMBL363049 | — | — | 1 | 4.88 |
| CHEMBL360669 | — | — | 1 | 4.85 |
| CHEMBL360009 | — | — | 1 | 4.76 |
| CHEMBL7889 | L-NIL | — | 1 | 4.76 |
| CHEMBL362366 | — | — | 1 | 4.57 |
| CHEMBL361909 | — | — | 1 | 4.28 |
| CHEMBL364781 | — | — | 1 | - |
| CHEMBL185867 | — | — | 1 | - |
| CHEMBL183268 | — | — | 1 | - |
| CHEMBL185505 | — | — | 1 | - |
| CHEMBL185600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185024 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL185584 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL363477 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL365849 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL184798 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL185161 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL185441 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL183012 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL359703 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL362148 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL185585 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL360616 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL182305 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL186142 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL161318 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL185535 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL361419 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL365637 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL363049 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL360669 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL360009 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL7889 | L-NIL | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL362366 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL361909 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL364781 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185867 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL183268 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185505 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL185600 | — | IC50 | > | 50000.0 | nM | - |