Assay Detail
Binding
CHEMBL831686
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Inhibition of Cyclin-dependent kinase 1-cyclin B
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B (CHEMBL2094127) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.62 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188587 | — | — | 1 | 7.52 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.52 |
| CHEMBL536272 | — | — | 1 | 7.16 |
| CHEMBL1790020 | — | — | 1 | 7.00 |
| CHEMBL188650 | — | — | 1 | 7.00 |
| CHEMBL363679 | — | — | 1 | 6.82 |
| CHEMBL186157 | — | — | 1 | 6.82 |
| CHEMBL433590 | — | — | 1 | 6.75 |
| CHEMBL187522 | — | — | 1 | 6.72 |
| CHEMBL187984 | — | — | 1 | 6.70 |
| CHEMBL365713 | — | — | 1 | 6.66 |
| CHEMBL425181 | — | — | 1 | 6.62 |
| CHEMBL362075 | — | — | 1 | 6.58 |
| CHEMBL187433 | — | — | 1 | 6.57 |
| CHEMBL433959 | — | — | 1 | 6.39 |
| CHEMBL188863 | — | — | 1 | 6.31 |
| CHEMBL187816 | — | — | 1 | 6.28 |
| CHEMBL418203 | — | — | 1 | 6.28 |
| CHEMBL362121 | — | — | 1 | 6.07 |
| CHEMBL364226 | — | — | 1 | 6.06 |
| CHEMBL370283 | — | — | 1 | 5.21 |
| CHEMBL187666 | — | — | 1 | - |
| CHEMBL191312 | — | — | 1 | - |
| CHEMBL190789 | — | — | 1 | - |
| CHEMBL188151 | — | — | 1 | - |
| CHEMBL436284 | — | — | 1 | - |
| CHEMBL190636 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188587 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL536272 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1790020 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL188650 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL363679 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL186157 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL433590 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL187522 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL187984 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL365713 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL425181 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL362075 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL187433 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL433959 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL188863 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL187816 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL418203 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL362121 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL364226 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL370283 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL187666 | — | IC50 | > | 270.0 | nM | - |
| CHEMBL191312 | — | IC50 | > | 510.0 | nM | - |
| CHEMBL190789 | — | IC50 | > | 260.0 | nM | - |
| CHEMBL188151 | — | IC50 | > | 560.0 | nM | - |
| CHEMBL436284 | — | IC50 | > | 270.0 | nM | - |
| CHEMBL190636 | — | IC50 | > | 270.0 | nM | - |