Assay Detail
Binding
CHEMBL831687
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Inhibition of Cyclin-dependent kinase 2-cyclin E
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E (CHEMBL2094126) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 7.03 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188587 | — | — | 1 | 8.05 |
| CHEMBL365713 | — | — | 1 | 8.00 |
| CHEMBL1790020 | — | — | 1 | 8.00 |
| CHEMBL536272 | — | — | 1 | 8.00 |
| CHEMBL433590 | — | — | 1 | 8.00 |
| CHEMBL363679 | — | — | 1 | 8.00 |
| CHEMBL187522 | — | — | 1 | 8.00 |
| CHEMBL187984 | — | — | 1 | 8.00 |
| CHEMBL188650 | — | — | 1 | 8.00 |
| CHEMBL186157 | — | — | 1 | 8.00 |
| CHEMBL436284 | — | — | 1 | 8.00 |
| CHEMBL187666 | — | — | 1 | 7.70 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.70 |
| CHEMBL363174 | — | — | 1 | 7.70 |
| CHEMBL425181 | — | — | 1 | 7.70 |
| CHEMBL190636 | — | — | 1 | 7.70 |
| CHEMBL190789 | — | — | 1 | 7.70 |
| CHEMBL362075 | — | — | 1 | 7.70 |
| CHEMBL187816 | — | — | 1 | 7.70 |
| CHEMBL188863 | — | — | 1 | 7.52 |
| CHEMBL433959 | — | — | 1 | 7.52 |
| CHEMBL187433 | — | — | 1 | 7.40 |
| CHEMBL361030 | — | — | 1 | 7.30 |
| CHEMBL364226 | — | — | 1 | 7.22 |
| CHEMBL362121 | — | — | 1 | 7.16 |
| CHEMBL363172 | — | — | 1 | 7.05 |
| CHEMBL418203 | — | — | 1 | 7.05 |
| CHEMBL190887 | — | — | 1 | 7.00 |
| CHEMBL366209 | — | — | 1 | 6.96 |
| CHEMBL191312 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188587 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL365713 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL436284 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL186157 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL188650 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL187984 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL363679 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL433590 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL536272 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1790020 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL187522 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL425181 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL363174 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL187666 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL190636 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL190789 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL362075 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL187816 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL188863 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL433959 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL187433 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL361030 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL364226 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL362121 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL363172 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL418203 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL190887 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL366209 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL191312 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL364858 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL188251 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL365144 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL191077 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL190091 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL364435 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL364001 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL187983 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL190317 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL370283 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL188151 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL187353 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL188812 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL190323 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL191519 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL188102 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL190738 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL191462 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL363715 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL443048 | — | IC50 | = | 2500.0 | nM | 5.60 |