Assay Detail
Binding
CHEMBL831695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HER1 kinase in intact DHER14 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | DHER14 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190094 | — | — | 1 | 8.40 |
| CHEMBL190651 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190094 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL190651 | — | IC50 | > | 250.0 | nM | - |