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Assay Detail

CHEMBL831708

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Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL ↗
64
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

C-C chemokine receptor type 3 (CHEMBL3473) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
De Lucca GV, Kim UT, Vargo BJ, Duncia JV, Santella JB, Gardner DS, Zheng C, Liauw A, Wang Z, Emmett G, Wacker DA, Welch PK, Covington M, Stowell NC, Wadman EA, Das AM, Davies P, Yeleswaram S, Graden DM, Solomon KA, Newton RC, Trainor GL, Decicco CP, Ko SS.
J Med Chem (2005) 48 : 2194 -2211
PubMed 15771462 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 64 8.44 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2113077 — — 1 9.52
CHEMBL2113074 — — 1 9.40
CHEMBL3706810 — — 1 9.15
CHEMBL277131 — — 1 9.15
CHEMBL363840 — — 1 9.15
CHEMBL364508 — — 1 9.05
CHEMBL195433 — — 1 9.05
CHEMBL382108 — — 1 9.00
CHEMBL3706812 — — 1 9.00
CHEMBL123611 — — 1 9.00
CHEMBL193575 — — 1 8.96
CHEMBL192240 — — 1 8.96
CHEMBL2113076 — — 1 8.92
CHEMBL2113079 — — 1 8.89
CHEMBL195555 — — 1 8.85
CHEMBL175634 — — 1 8.85
CHEMBL195044 — — 1 8.85
CHEMBL365820 — — 1 8.82
CHEMBL176077 — — 1 8.80
CHEMBL3706813 — — 1 8.80
CHEMBL2113080 — — 1 8.77
CHEMBL3706811 — — 1 8.74
CHEMBL193330 — — 1 8.74
CHEMBL195348 — — 1 8.72
CHEMBL365732 — — 1 8.72
CHEMBL195129 — — 1 8.72
CHEMBL250689 — — 1 8.70
CHEMBL194601 — — 1 8.70
CHEMBL373347 — — 1 8.70
CHEMBL364068 — — 1 8.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2113077 — IC50 = 0.3 nM 9.52
CHEMBL2113074 — IC50 = 0.4 nM 9.40
CHEMBL277131 — IC50 = 0.7 nM 9.15
CHEMBL363840 — IC50 = 0.7 nM 9.15
CHEMBL3706810 — IC50 = 0.7 nM 9.15
CHEMBL364508 — IC50 = 0.9 nM 9.05
CHEMBL195433 — IC50 = 0.9 nM 9.05
CHEMBL382108 — IC50 = 1.0 nM 9.00
CHEMBL3706812 — IC50 = 1.0 nM 9.00
CHEMBL123611 — IC50 = 1.0 nM 9.00
CHEMBL193575 — IC50 = 1.1 nM 8.96
CHEMBL192240 — IC50 = 1.1 nM 8.96
CHEMBL2113076 — IC50 = 1.2 nM 8.92
CHEMBL2113079 — IC50 = 1.3 nM 8.89
CHEMBL195044 — IC50 = 1.4 nM 8.85
CHEMBL195555 — IC50 = 1.4 nM 8.85
CHEMBL175634 — IC50 = 1.4 nM 8.85
CHEMBL365820 — IC50 = 1.5 nM 8.82
CHEMBL176077 — IC50 = 1.6 nM 8.80
CHEMBL3706813 — IC50 = 1.6 nM 8.80
CHEMBL2113080 — IC50 = 1.7 nM 8.77
CHEMBL3706811 — IC50 = 1.8 nM 8.74
CHEMBL193330 — IC50 = 1.8 nM 8.74
CHEMBL365732 — IC50 = 1.9 nM 8.72
CHEMBL195129 — IC50 = 1.9 nM 8.72
CHEMBL195348 — IC50 = 1.9 nM 8.72
CHEMBL194601 — IC50 = 2.0 nM 8.70
CHEMBL250689 — IC50 = 2.0 nM 8.70
CHEMBL373347 — IC50 = 2.0 nM 8.70
CHEMBL364068 — IC50 = 2.2 nM 8.66
CHEMBL363373 — IC50 = 2.3 nM 8.64
CHEMBL364977 — IC50 = 2.3 nM 8.64
CHEMBL370082 — IC50 = 2.5 nM 8.60
CHEMBL370082 — IC50 = 2.5 nM 8.60
CHEMBL362466 — IC50 = 2.5 nM 8.60
CHEMBL46905 — IC50 = 2.5 nM 8.60
CHEMBL368683 — IC50 = 2.6 nM 8.59
CHEMBL193526 — IC50 = 2.7 nM 8.57
CHEMBL428881 — IC50 = 3.0 nM 8.52
CHEMBL369073 — IC50 = 3.0 nM 8.52
CHEMBL367992 — IC50 = 4.0 nM 8.40
CHEMBL195790 — IC50 = 4.0 nM 8.40
CHEMBL363166 — IC50 = 4.0 nM 8.40
CHEMBL364673 — IC50 = 4.6 nM 8.34
CHEMBL194141 — IC50 = 5.0 nM 8.30
CHEMBL193442 — IC50 = 6.0 nM 8.22
CHEMBL2096696 — IC50 = 9.0 nM 8.05
CHEMBL2096764 — IC50 = 9.0 nM 8.05
CHEMBL175679 — IC50 = 9.0 nM 8.05
CHEMBL364263 — IC50 = 10.0 nM 8.00