Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL831867

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of calcium mobilization in human eosinophils
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

C-C chemokine receptor type 3 (CHEMBL3473)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
De Lucca GV, Kim UT, Vargo BJ, Duncia JV, Santella JB, Gardner DS, Zheng C, Liauw A, Wang Z, Emmett G, Wacker DA, Welch PK, Covington M, Stowell NC, Wadman EA, Das AM, Davies P, Yeleswaram S, Graden DM, Solomon KA, Newton RC, Trainor GL, Decicco CP, Ko SS.
J Med Chem (2005) 48 : 2194 -2211
PubMed 15771462 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 8.25 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL363840 1 9.00
CHEMBL195555 1 8.70
CHEMBL382108 1 8.70
CHEMBL193575 1 8.70
CHEMBL2113074 1 8.70
CHEMBL2113077 1 8.70
CHEMBL373347 1 8.40
CHEMBL365820 1 8.40
CHEMBL3706810 1 8.40
CHEMBL195433 1 8.40
CHEMBL250689 1 8.10
CHEMBL175634 1 8.00
CHEMBL362466 1 7.77
CHEMBL363166 1 7.46
CHEMBL193442 1 7.30
CHEMBL194141 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL363840 IC50 = 1.0 nM 9.00
CHEMBL195555 IC50 = 2.0 nM 8.70
CHEMBL382108 IC50 = 2.0 nM 8.70
CHEMBL193575 IC50 = 2.0 nM 8.70
CHEMBL2113074 IC50 = 2.0 nM 8.70
CHEMBL2113077 IC50 = 2.0 nM 8.70
CHEMBL373347 IC50 = 4.0 nM 8.40
CHEMBL365820 IC50 = 4.0 nM 8.40
CHEMBL3706810 IC50 = 4.0 nM 8.40
CHEMBL195433 IC50 = 4.0 nM 8.40
CHEMBL250689 IC50 = 8.0 nM 8.10
CHEMBL175634 IC50 = 10.0 nM 8.00
CHEMBL362466 IC50 = 17.0 nM 7.77
CHEMBL363166 IC50 = 35.0 nM 7.46
CHEMBL193442 IC50 = 50.0 nM 7.30
CHEMBL194141 IC50 = 50.0 nM 7.30