Assay Detail
Functional
CHEMBL831911
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro agonistic activity against opioid receptor delta of mouse vas deferens
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 22.(1) Influence of the 14-alkoxy group and the substitution in position 5 in 14-alkoxymorphinan-6-ones on in vitro and in vivo activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.71 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL607407 | — | — | 1 | 9.10 |
| CHEMBL607351 | — | — | 1 | 8.82 |
| CHEMBL607482 | — | — | 1 | 8.64 |
| CHEMBL607406 | — | — | 1 | 8.01 |
| CHEMBL326684 | — | — | 1 | 7.61 |
| CHEMBL607405 | — | — | 1 | 7.52 |
| CHEMBL607404 | — | — | 1 | 7.20 |
| CHEMBL607483 | — | — | 1 | 6.68 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL607407 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL607351 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL607482 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL607406 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL326684 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL607405 | — | IC50 | = | 30.5 | nM | 7.52 |
| CHEMBL607404 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL607483 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL70 | MORPHINE | IC50 | = | 1600.0 | nM | 5.80 |