Assay Detail
Binding
CHEMBL831968
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Inhibitory concentration against Acetylcholinesterase from bovine erythrocytes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.65 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2113368 | — | — | 1 | 9.48 |
| CHEMBL555666 | — | — | 1 | 9.40 |
| CHEMBL557155 | — | — | 1 | 9.32 |
| CHEMBL2113367 | — | — | 1 | 9.27 |
| CHEMBL555214 | — | — | 1 | 8.97 |
| CHEMBL534932 | — | — | 1 | 8.90 |
| CHEMBL538573 | — | — | 1 | 8.71 |
| CHEMBL539599 | — | — | 1 | 8.68 |
| CHEMBL535812 | — | — | 1 | 8.66 |
| CHEMBL536047 | — | — | 1 | 8.37 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.13 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | 4.0 | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2113368 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL555666 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL557155 | — | IC50 | = | 0.48 | nM | 9.32 |
| CHEMBL2113367 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL555214 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL534932 | — | IC50 | = | 1.26 | nM | 8.90 |
| CHEMBL538573 | — | IC50 | = | 1.97 | nM | 8.71 |
| CHEMBL539599 | — | IC50 | = | 2.09 | nM | 8.68 |
| CHEMBL535812 | — | IC50 | = | 2.19 | nM | 8.66 |
| CHEMBL536047 | — | IC50 | = | 4.23 | nM | 8.37 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL1677 | TACRINE HYDROCHLORIDE | IC50 | = | 130.0 | nM | 6.89 |