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Assay Detail

CHEMBL832082

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against dual-specificity phosphatase Cell division cycle (Cdc) 25B
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

M-phase inducer phosphatase 2 (CHEMBL4804)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue.
Shimazawa R, Gochomori M, Shirai R.
Bioorg Med Chem Lett (2004) 14 : 4339 -4342
PubMed 15261298 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.48 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL182548 1 5.92
CHEMBL181800 1 5.89
CHEMBL181850 1 5.77
CHEMBL179992 1 5.52
CHEMBL182673 1 5.48
CHEMBL182645 1 5.43
CHEMBL181052 1 5.35
CHEMBL362416 1 5.30
CHEMBL181815 1 5.24
CHEMBL332036 1 5.23
CHEMBL181402 1 5.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL182548 IC50 = 1200.0 nM 5.92
CHEMBL181800 IC50 = 1300.0 nM 5.89
CHEMBL181850 IC50 = 1700.0 nM 5.77
CHEMBL179992 IC50 = 3000.0 nM 5.52
CHEMBL182673 IC50 = 3300.0 nM 5.48
CHEMBL182645 IC50 = 3700.0 nM 5.43
CHEMBL181052 IC50 = 4500.0 nM 5.35
CHEMBL362416 IC50 = 5000.0 nM 5.30
CHEMBL181815 IC50 = 5800.0 nM 5.24
CHEMBL332036 IC50 = 5900.0 nM 5.23
CHEMBL181402 IC50 = 6800.0 nM 5.17