Assay Detail
Binding
CHEMBL832085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of baculovirus expressed human trkA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
High affinity nerve growth factor receptor (CHEMBL2815) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, modeling, and in vitro activity of (3'S)-epi-K-252a analogues. Elucidating the stereochemical requirements of the 3'-sugar alcohol on trkA tyrosine kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.24 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL94678 | — | — | 1 | 8.92 |
| CHEMBL2113064 | — | — | 1 | 8.54 |
| CHEMBL2113063 | — | — | 1 | 8.52 |
| CHEMBL365585 | — | — | 1 | 8.40 |
| CHEMBL370493 | — | — | 1 | 8.40 |
| CHEMBL281948 | K-252A | — | 1 | 7.89 |
| CHEMBL2113062 | — | — | 1 | 7.70 |
| CHEMBL2113065 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL94678 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2113064 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL2113063 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL365585 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL370493 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL281948 | K-252A | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2113062 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2113065 | — | IC50 | = | 29.0 | nM | 7.54 |