Assay Detail
Binding
CHEMBL832147
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In vitro inhibitory concentration was measured against quiescent cell proline dipeptidase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.10 | 4.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL537844 | — | — | 1 | 4.19 |
| CHEMBL558585 | — | — | 1 | 4.11 |
| CHEMBL558196 | — | — | 1 | 4.01 |
| CHEMBL537625 | — | — | 1 | - |
| CHEMBL537400 | — | — | 1 | - |
| CHEMBL539077 | — | — | 1 | - |
| CHEMBL557187 | — | — | 1 | - |
| CHEMBL559011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL537844 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL558585 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL558196 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL537625 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL537400 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL539077 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL557187 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL559011 | — | IC50 | > | 100000.0 | nM | - |