Assay Detail
Binding
CHEMBL832203
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Inhibitory concentration against acetylcholinesterase of rat cortex homogenate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.97 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176132 | BIS(18)-HUPERZINE B | — | 1 | 8.31 |
| CHEMBL434898 | BIS(16)-HUPERZINE B | — | 1 | 7.73 |
| CHEMBL368897 | BIS(20)-HUPERZINE B | — | 1 | 7.60 |
| CHEMBL368899 | — | — | 1 | 7.45 |
| CHEMBL435673 | — | — | 1 | 7.29 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.14 |
| CHEMBL175975 | BIS(12)-HUPERZINE B | — | 1 | 7.12 |
| CHEMBL367977 | BIS(9)-HUPERZINE B | — | 1 | 6.33 |
| CHEMBL360092 | BIS(8)-HUPERZINE B | — | 1 | 5.99 |
| CHEMBL245079 | HUPERZINE B | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176132 | BIS(18)-HUPERZINE B | IC50 | = | 4.93 | nM | 8.31 |
| CHEMBL434898 | BIS(16)-HUPERZINE B | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL368897 | BIS(20)-HUPERZINE B | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL368899 | — | IC50 | = | 35.9 | nM | 7.45 |
| CHEMBL435673 | — | IC50 | = | 50.8 | nM | 7.29 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 72.4 | nM | 7.14 |
| CHEMBL175975 | BIS(12)-HUPERZINE B | IC50 | = | 76.2 | nM | 7.12 |
| CHEMBL367977 | BIS(9)-HUPERZINE B | IC50 | = | 471.0 | nM | 6.33 |
| CHEMBL360092 | BIS(8)-HUPERZINE B | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL245079 | HUPERZINE B | IC50 | = | 19300.0 | nM | 4.71 |