Assay Detail
Binding
CHEMBL832206
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Concentration required for 50% inhibition by displacement of of [125I]NDP-alpha-MSH of human MC4R expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.05 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433764 | — | — | 1 | 9.43 |
| CHEMBL362523 | — | — | 1 | 9.25 |
| CHEMBL360818 | — | — | 1 | 9.11 |
| CHEMBL2113041 | — | — | 1 | 8.96 |
| CHEMBL360819 | — | — | 1 | 8.96 |
| CHEMBL339053 | — | — | 1 | 8.92 |
| CHEMBL187990 | — | — | 1 | 8.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433764 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL362523 | — | IC50 | = | 0.56 | nM | 9.25 |
| CHEMBL360818 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL2113041 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL360819 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL339053 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL187990 | — | IC50 | = | 1.9 | nM | 8.72 |