Assay Detail
Binding
CHEMBL832299
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Inhibition of human recombinant Mitogen activated protein kinase p38 alpha activity using ATP[gamma-33P] and EGFR 21mer-peptide
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.05 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191113 | — | — | 1 | 8.57 |
| CHEMBL192848 | — | — | 1 | 8.38 |
| CHEMBL192850 | — | — | 1 | 8.37 |
| CHEMBL363831 | — | — | 1 | 8.36 |
| CHEMBL364925 | — | — | 1 | 8.35 |
| CHEMBL191053 | — | — | 1 | 8.33 |
| CHEMBL190514 | — | — | 1 | 8.32 |
| CHEMBL364572 | — | — | 1 | 8.31 |
| CHEMBL371145 | — | — | 1 | 8.26 |
| CHEMBL192889 | — | — | 1 | 7.82 |
| CHEMBL193055 | — | — | 1 | 7.80 |
| CHEMBL193247 | — | — | 1 | 7.70 |
| CHEMBL193305 | — | — | 1 | 7.68 |
| CHEMBL363852 | — | — | 1 | 7.64 |
| CHEMBL434957 | — | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191113 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL192848 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL192850 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL363831 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL364925 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL191053 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL190514 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL364572 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL371145 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL192889 | — | IC50 | = | 15.3 | nM | 7.82 |
| CHEMBL193055 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL193247 | — | IC50 | = | 19.9 | nM | 7.70 |
| CHEMBL193305 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL363852 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL434957 | — | IC50 | = | 125.0 | nM | 6.90 |